A recent college graduate (Brener) decides to sell marijuana on the streets of Manhattan after losing his job at a consulting firm. He soon meets the girl of his dreams (Daddario). With an unsupportive girlfriend, an increase of clienteles, and the growing threats of being caught or killed, he soon realizes he is in way over his head. 《我在曼哈顿卖大麻》的别名有：Unreachable by Conventional Means。